Pregabalin, yemwe amadziwikanso ndi dzina la Lyrica, ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda osiyanasiyana monga ululu wa neuropathic, fibromyalgia, khunyu, komanso matenda oda nkhawa ambiri.Ndi m'gulu la mankhwala otchedwa anticonvulsants, omwe amagwira ntchito pochepetsa mphamvu yamagetsi mu ubongo.Koma kodi munayamba mwadzifunsapo momwe pregabalin imagwirira ntchito m'thupi?
Zochita za Pregabalin zimagwirizana kwambiri ndi kuthekera kwake kumangirira kumtundu wina wa calcium m'katikati mwa mitsempha.Njirazi zimakhudzidwa ndi kutulutsidwa kwa ma neurotransmitters, omwe ndi amithenga amankhwala omwe amatumiza mauthenga pakati pa ma cell a mitsempha.Pomangiriza ku njirazi, pregabalin imachepetsa kutulutsidwa kwa ma neurotransmitters ena, kuphatikizapo glutamate, norepinephrine, ndi substance P. Kusinthidwa kwa neurotransmitter kumasulidwa kumakhulupirira kuti kumathandiza kuti pregabalin ikhale ndi zotsatira zochiritsira.
Chimodzi mwamakina ofunikira a pregabalin ndikutha kwake kuchepetsa kutulutsidwa kwa glutamate, neurotransmitter yoyamba yosangalatsa m'kati mwa dongosolo lamanjenje.Pochita zimenezi, pregabalin imathandizira kuchepetsa zizindikiro zowonongeka pakati pa mitsempha ya mitsempha, yomwe nthawi zambiri imagwirizanitsidwa ndi zinthu monga ululu wa neuropathic ndi khunyu.Izi zimaganiziridwa kuti zimathandizira kuti pregabalin athe kuchepetsa ululu komanso kuchepetsa ntchito ya khunyu.
Kuphatikiza pa zotsatira zake pa glutamate, pregabalin imachepetsanso kutulutsidwa kwa norepinephrine, neurotransmitter yomwe imakhudzidwa ndi kuyankha kupsinjika kwa thupi komanso kukonza ululu.Posintha kutulutsidwa kwa norepinephrine, pregabalin ingathandize kuchepetsa zizindikiro za matenda ovutika maganizo ndi fibromyalgia, zomwe zimaganiziridwa kuti zimaphatikizapo kusokonekera kwa dongosolo loyankha kupsinjika kwa thupi.
Komanso, pregabalin yasonyezedwa kuti imachepetsa kutulutsidwa kwa mankhwala P, neurotransmitter yomwe imakhudzidwa ndi kufalitsa zizindikiro za ululu mumsana.Pochepetsa kutulutsidwa kwa chinthu P, pregabalin ingathandize kuchepetsa ululu wa neuropathic, womwe nthawi zambiri umadziwika ndi kupweteka kwachilendo mu dongosolo la mitsempha.
Ponseponse, zochita za pregabalin ndizovuta ndipo zimaphatikizapo kusinthika kwa ma neurotransmitter mu dongosolo lapakati lamanjenje.Poyang'ana njira zina za kashiamu ndikuchepetsa kutulutsidwa kwa ma neurotransmitters ofunikira, pregabalin imatha kupereka chithandizo chamankhwala pamikhalidwe yosiyanasiyana, kuphatikiza ululu wa neuropathic, khunyu, fibromyalgia, ndi matenda oda nkhawa ambiri.
Ndikofunikira kudziwa kuti ngakhale njira ya pregabalin imamveka bwino, mayankho amunthu payekha pamankhwala amatha kusiyana.Anthu ena amatha kukhala ndi mpumulo waukulu kuzizindikiro zawo, pomwe ena sangayankhenso.Kuonjezera apo, monga mankhwala onse, pregabalin ikhoza kukhala ndi zotsatira zake, ndipo ndikofunika kukambirana ndi wothandizira zaumoyo wanu nkhawa iliyonse.
Pomaliza, kumvetsetsa zochita za pregabalin kungapereke chidziwitso chofunikira cha momwe mankhwalawa amagwirira ntchito kuti athetse matenda osiyanasiyana.Poyang'ana machitidwe ena a neurotransmitter mu dongosolo lapakati lamanjenje, pregabalin imapereka njira zingapo zochepetsera zizindikiro.Ngati muli ndi mafunso kapena nkhawa zokhudzana ndi pregabalin, onetsetsani kuti mwapeza malangizo kuchokera kwa katswiri wazachipatala.
Nthawi yotumiza: Feb-17-2024
