I-Pregabalin, eyaziwa ngegama le-brand ye-Lyrica, liyeza elisetyenziselwa ukunyanga iimeko ezahlukeneyo ezifana neentlungu ze-neuropathic, i-fibromyalgia, isifo sokuwa, kunye nokuphazamiseka kokuxhalabisa ngokubanzi.Yeyodidi lwamachiza abizwa ngokuba zii-anticonvulsants, asebenza ngokunciphisa ukusebenza kombane okungaqhelekanga engqondweni.Kodwa ngaba ukhe wazibuza ukuba i-pregabalin isebenza njani ngokwenene emzimbeni?
Isenzo se-Pregabalin ngokuyinhloko sinxulumene nokukwazi ukubopha kuhlobo oluthile lwesiteshi se-calcium kwinkqubo ye-nervous central.Ezi tshaneli zibandakanyeka ekukhululweni kwee-neurotransmitters, ezizizithunywa zeekhemikhali ezihambisa imiqondiso phakathi kweeseli zemithambo-luvo.Ngokuzibophelela kula matshaneli, i-pregabalin inciphisa ukukhululwa kwee-neurotransmitters ezithile, kuquka i-glutamate, i-norepinephrine, kunye ne-substance P. Le modulation yokukhululwa kwe-neurotransmitter ikholelwa ukuba igalelo kwimiphumo ye-pregabalin yonyango.
Enye yeendlela eziphambili zesenzo se-pregabalin kukukwazi ukunciphisa ukukhululwa kwe-glutamate, i-neurotransmitter ephambili ye-excitatory kwinkqubo ye-nervous central.Ngokwenza njalo, i-pregabalin inceda ukudambisa ukubonakaliswa okugqithisileyo phakathi kweeseli ze-nerve, ezihlala zihambelana neemeko ezinjengeentlungu ze-neuropathic kunye nokuxhuzula.Esi siphumo sicingelwa ukuba sinegalelo kwisakhono se-pregabalin sokunciphisa intlungu kunye nokunciphisa umsebenzi wokubamba.
Ukongeza kwimiphumo yayo kwi-glutamate, i-pregabalin iphinda inciphise ukukhululwa kwe-norepinephrine, i-neurotransmitter ebandakanyekayo ekuphenduleni uxinzelelo lomzimba kunye nokucubungula intlungu.Ngokumodareyitha ukukhululwa kwe-norepinephrine, i-pregabalin inokunceda ukunciphisa iimpawu zengxaki yokukhathazeka ngokubanzi kunye ne-fibromyalgia, zombini ezo zicingelwa ukuba zibandakanya ukuxhatshazwa kwenkqubo yokuphendula uxinzelelo lomzimba.
Ngaphezu koko, i-pregabalin ibonakaliswe ukunciphisa ukukhululwa kwezinto P, i-neurotransmitter ebandakanyekayo ekuhanjisweni kweempawu zentlungu kwintambo yomgogodla.Ngokunciphisa ukukhululwa kwe-substance P, i-pregabalin inokunceda ukunciphisa intlungu ye-neuropathic, ehlala ibonakaliswe ngokugqithiswa kweentlungu ezingaqhelekanga kwinkqubo ye-nervous.
Ngokubanzi, isenzo se-pregabalin sinzima kwaye sibandakanya ukumodareyithwa kokukhululwa kwe-neurotransmitter kwinkqubo ye-nervous central.Ngokujolisa iziteshi ezithile ze-calcium kunye nokunciphisa ukukhutshwa kwee-neurotransmitters eziphambili, i-pregabalin inokubonelela ngeenzuzo zonyango kwiintlobo ezahlukeneyo zeemeko, kubandakanywa intlungu ye-neuropathic, i-epilepsy, i-fibromyalgia, kunye nokukhathazeka ngokubanzi.
Kubalulekile ukuqaphela ukuba ngelixa indlela yokusebenza ye-pregabalin iqondwa kakuhle, iimpendulo zomntu ngamnye kwiyeza zinokwahluka.Abanye abantu banokufumana isiqabu esibonakalayo kwiimpawu zabo, ngelixa abanye basenokungaphenduli nabo.Ukongezelela, njengawo onke amayeza, i-pregabalin ingaba nemiphumo emibi, kwaye kubalulekile ukuxoxa ngayo nayiphi na inkxalabo kunye nomboneleli wakho wezempilo.
Ukuqukumbela, ukuqonda isenzo se-pregabalin kunokubonelela ngengqiqo ebalulekileyo malunga nendlela eli yeza elisebenza ngayo ukunciphisa iimeko zempilo ezahlukeneyo.Ngokujolisa kwiinkqubo ezithile ze-neurotransmitter kwinkqubo ye-nervous central, i-pregabalin inikezela ngeendlela ezininzi zokunciphisa iimpawu.Ukuba unayo nayiphi na imibuzo okanye iinkxalabo malunga ne-pregabalin, qiniseka ukuba ufuna isikhokelo kwingcali yezempilo.
Ixesha lokuposa: Feb-17-2024
