Pregabalin, eo hangata e tsejoang ka lebitso la eona la Lyrica, ke moriana o sebelisetsoang ho phekola maemo a fapaneng a kang neuropathic pain, fibromyalgia, lefu la sethoathoa le lefu la ho tšoenyeha ka kakaretso.Ke ea sehlopha sa lithethefatsi tse bitsoang li-anticonvulsants, tse sebetsang ka ho fokotsa tšebetso e sa tloaelehang ea motlakase bokong.Empa na u kile ua ipotsa hore na pregabalin e hlile e sebetsa joang 'meleng?
Ketso ea Pregabalin e amana haholo-holo le bokhoni ba eona ba ho tlama mofuta o itseng oa mocha oa calcium tsamaisong ea methapo e bohareng.Mecha ena e ameha ho lokolloeng ha li-neurotransmitters, e leng manqosa a lik’hemik’hale a fetisang melaetsa lipakeng tsa lisele tsa methapo.Ka ho tlama likanale tsena, pregabalin e fokotsa ho lokolloa ha li-neurotransmitters tse itseng, ho akarelletsa le glutamate, norepinephrine, le substance P. Ho lumeloa hore ho feto-fetoha hona ha neurotransmitter ho kenya letsoho liphellong tsa phekolo ea pregabalin.
E 'ngoe ea mekhoa ea bohlokoa ea ts'ebetso ea pregabalin ke bokhoni ba eona ba ho fokotsa ho lokolloa ha glutamate, neurotransmitter e ka sehloohong e tsosang takatso tsamaisong ea methapo e bohareng.Ka ho etsa joalo, pregabalin e thusa ho fokotsa pontšo e feteletseng pakeng tsa lisele tsa methapo, tse atisang ho amahanngoa le maemo a kang bohloko ba neuropathic le lefu la sethoathoa.Phello ena ho nahanoa hore e kenya letsoho ho matla a pregabalin a ho kokobetsa bohloko le ho fokotsa ts'ebetso ea ho tsietsana.
Ntle le liphello tsa eona ho glutamate, pregabalin e boetse e fokotsa ho lokolloa ha norepinephrine, neurotransmitter e amehang karabelong ea 'mele ea khatello ea kelello le ho sebetsana le bohloko.Ka ho fetola ho lokolloa ha norepinephrine, pregabalin e ka thusa ho fokotsa matšoao a lefu la ho tšoenyeha le tloaelehileng le fibromyalgia, tseo ka bobeli ho nahanoang hore li kenyelletsa ho senyeha ha tsamaiso ea 'mele ea ho arabela khatello ea kelello.
Ho feta moo, pregabalin e bontšitsoe ho fokotsa ho lokolloa ha ntho P, neurotransmitter e amehang phetisong ea matšoao a bohloko mokokotlong oa mokokotlo.Ka ho fokotsa ho lokolloa ha ntho ea P, pregabalin e ka thusa ho fokotsa bohloko ba neuropathic, boo hangata bo khetholloang ke ho sebetsana le bohloko bo sa tloaelehang tsamaisong ea methapo.
Ka kakaretso, ketso ea pregabalin e rarahane 'me e kenyelletsa modulation ea ho lokolloa ha neurotransmitter tsamaisong ea methapo e bohareng.Ka ho lebisa liteishene tse khethehileng tsa khalsiamo le ho fokotsa ho lokolloa ha li-neurotransmitters tsa bohlokoa, pregabalin e ka fana ka melemo ea phekolo bakeng sa maemo a mangata, ho akarelletsa le bohloko ba neuropathic, lefu la sethoathoa, fibromyalgia, le lefu la ho tšoenyeha ka kakaretso.
Ke habohlokoa ho hlokomela hore le hoja mokhoa oa ts'ebetso oa pregabalin o utloisisoa hantle, likarabo tsa motho ka mong ho meriana li ka fapana.Batho ba bang ba ka 'na ba imoloha haholo matšoao a bona, ha ba bang ba ka' na ba se ke ba arabela hantle.Ho phaella moo, joaloka meriana eohle, pregabalin e ka ba le litla-morao, 'me ke habohlokoa ho buisana le mofani oa hao oa tlhokomelo ea bophelo ka mathata leha e le afe.
Qetellong, ho utloisisa ketso ea pregabalin ho ka fana ka temohisiso ea bohlokoa ea hore na moriana ona o sebetsa joang ho fokotsa maemo a fapaneng a bophelo bo botle.Ka ho shebana le litsamaiso tse khethehileng tsa li-neurotransmitter tsamaisong ea methapo e bohareng, pregabalin e fana ka mokhoa o fapaneng oa ho imolla matšoao.Haeba u na le lipotso kapa lintho tse u tšoenyang ka pregabalin, etsa bonnete ba hore u batla tataiso ho setsebi sa bophelo bo botle.
Nako ea poso: Feb-17-2024
