I-Pregabalin, evame ukubizwa ngegama lomkhiqizo i-Lyrica, umuthi osetshenziselwa ukwelapha izimo ezahlukahlukene ezinjengobuhlungu be-neuropathic, i-fibromyalgia, isithuthwane, kanye nesifo sokukhathazeka esijwayelekile.Ingokwesigaba sezidakamizwa ezibizwa ngokuthi ama-anticonvulsants, ezisebenza ngokunciphisa ukusebenza kukagesi okungavamile ebuchosheni.Kodwa wake wazibuza ukuthi empeleni i-pregabalin isebenza kanjani emzimbeni?
Isenzo sikaPregabalin sihlobene ngokuyinhloko nekhono layo lokubopha ohlotsheni oluthile lwesiteshi se-calcium ohlelweni lwezinzwa olumaphakathi.Lezi ziteshi zihilelekile ekukhishweni kwama-neurotransmitters, okuyizithunywa zamakhemikhali ezidlulisa amasignali phakathi kwamangqamuzana ezinzwa.Ngokubophezela kulawa mashaneli, i-pregabalin yehlisa ukukhululwa kwama-neurotransmitters athile, okuhlanganisa i-glutamate, i-norepinephrine, kanye ne-substance P. Lokhu kuguqulwa kokukhishwa kwe-neurotransmitter kukholakala ukuthi kunesandla emiphumeleni yokwelapha ye-pregabalin.
Enye yezindlela eziyinhloko zesenzo se-pregabalin yikhono layo lokunciphisa ukukhululwa kwe-glutamate, i-neurotransmitter eyinhloko ejabulisayo ohlelweni lwezinzwa oluphakathi.Ngokwenza kanjalo, i-pregabalin isiza ukudambisa ukubonakaliswa okunamandla phakathi kwamaseli ezinzwa, okuvame ukuhlotshaniswa nezimo ezifana nobuhlungu be-neuropathic kanye nesifo sokuwa.Lo mphumela kucatshangwa ukuthi unomthelela ekhonweni le-pregabalin lokudambisa izinhlungu kanye nokunciphisa umsebenzi wokuquleka.
Ngaphezu kwemiphumela yayo ku-glutamate, i-pregabalin iphinde inciphise ukukhululwa kwe-norepinephrine, i-neurotransmitter ehilelekile ekuphenduleni kokucindezeleka komzimba nokucubungula ubuhlungu.Ngokulinganisa ukukhululwa kwe-norepinephrine, i-pregabalin ingasiza ekudambiseni izimpawu zesifo sokukhathazeka esivamile kanye ne-fibromyalgia, kokubili okucatshangwa ukuthi kuhilela ukungasebenzi kahle kwesistimu yokuphendula ukucindezeleka komzimba.
Ngaphezu kwalokho, i-pregabalin iboniswe ukunciphisa ukukhululwa kwe-substance P, i-neurotransmitter ehilelekile ekudlulisweni kwezimpawu zobuhlungu emthonjeni womgogodla.Ngokunciphisa ukukhululwa kwe-substance P, i-pregabalin ingasiza ekunciphiseni ubuhlungu be-neuropathic, obuvame ukubonakala ngokucubungula ubuhlungu obungavamile ohlelweni lwezinzwa.
Sekukonke, isenzo se-pregabalin siyinkimbinkimbi futhi sibandakanya ukuguqulwa kokukhululwa kwe-neurotransmitter ohlelweni lwezinzwa olumaphakathi.Ngokuqondisa iziteshi ezithile ze-calcium nokunciphisa ukukhululwa kwama-neurotransmitters abalulekile, i-pregabalin inganikeza izinzuzo zokwelapha ngezinhlobonhlobo zezimo, kuhlanganise nobuhlungu be-neuropathic, isithuthwane, i-fibromyalgia, nesifo sokukhathazeka okujwayelekile.
Kubalulekile ukuqaphela ukuthi nakuba indlela yokusebenza ye-pregabalin iqondwa kahle, izimpendulo zomuntu ngamunye emuthini zingahluka.Abanye abantu bangase bathole ukukhululeka okukhulu ezimpawini zabo, kuyilapho abanye bengase bangaphenduli.Ukwengeza, njengayo yonke imithi, i-pregabalin ingaba nemiphumela engemihle, futhi kubalulekile ukuxoxa nganoma yikuphi ukukhathazeka nomhlinzeki wakho wezempilo.
Sengiphetha, ukuqonda isenzo se-pregabalin kunganikeza ukuqonda okubalulekile kokuthi lo muthi usebenza kanjani ukuze udambise izimo zezempilo ezahlukahlukene.Ngokuqondisa izinhlelo ezithile ze-neurotransmitter ohlelweni lwezinzwa olumaphakathi, i-pregabalin inikezela ngendlela enezinhlangothi eziningi zokukhululeka kwezimpawu.Uma unemibuzo noma ukukhathazeka mayelana ne-pregabalin, qiniseka ukuthi ufuna isiqondiso kuchwepheshe wezokunakekelwa kwempilo.
Isikhathi sokuthumela: Feb-17-2024
